Fig. 1

Geographical distribution of centre contribution to IRIS study. Italy map, geographical distribution of center contribution to database, percentage of cases for each region. All analyses were performed using R Statistical Software (v4.1.2; R Core Team 2021). Italy Maps was obtained via the ggplot2 R package (v3.4.4; Wickham 2016), the tidyverse R package (v2.0.0; Wickham et al. 2019), rnaturalearth R package (v3.4; Massicotte and South 2023)