Table 3 Outcomes of the included studies
Study | Follow-up | Outcomes | Comments |
|---|---|---|---|
Mazeh, et al. 2012 [18] | 17.1 months (range 4–28 months) Group A: 16.4 ± 5.0 months Group B: 17.7 ± 6.0 months | Postoperative complication rate Group A: 0% Group B: 7.7% Positive bile cultures Group A: 22% Group B: 12% | The course of the disease with the use of antibiotics did not change significantly compared to the group without antibiotics. The use of antibiotics may result in bacterial overgrowth. Late cholecystectomy is performed, but the standard of care nowadays is early cholecystectomy. |
Park, et al. 2022 [19] | Not reported | Postoperative complication rate Group A: 25.6% Group B: 23.8% Postoperative infection rate Group A: 8.8% Group B: 7.4% Positive bile cultures Group A: 16.8% Group B: 12.3% | The absence of preoperative antibiotics does not increase the rate of infectious and non-infectious complications. There was a higher proportion of positive cultures in patients who received antibiotics. Cholecystectomy was performed within the first 24 h, which is ideal. However, in the clinical setting, it is not always possible to perform the surgical procedure within the first 24 h. |