Table 2 Characteristics of the included studies
Study | Location | Type of study | Total of patients | Time to cholecystectomy | Inclusion criteria | Intervention |
|---|---|---|---|---|---|---|
Mazeh, et al. 2012 [18] | Jerusalem, Israel | RCT | 84 patients Group A: 42 patients Group B: 42 patients | Group A: 58 (17–156) days Group B: 55 (17–240) days | Mild acute cholecystitis Patients were 18 to 70 years old | Group A: amoxicillin clavulanate (Augmentin) (1 g IV every 8 h) until discharge. Patients allergic to penicillin (n = 12) were treated with a combination of ciprofloxacin (400 mg IV every 12 h) and metronidazole (500 mg IV every 8 h). Group B: nonantibiotic treatment. Supportive care. |
Park, et al. 2022 [19] | Seoul, Korea | RCT | 247 patients Group A: 125 patients Group B: 122 patients | First 24 h | Mild and moderate acute cholecystitis (without empyema, gangrenous, perforation, or peritonitis) | Group A: 1.0 g of first-generation cephalosporin (cefazolin). Group B: 10 mL of intravenous normal saline. |