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Table 1 Characteristics of the patients

From: Early administration of fibrinogen concentrate is associated with improved survival among severe trauma patients: a single-centre propensity score-matched analysis

 

Control group

n = 110

FC group

n = 38

p value

Age (year)

54 (39–71)

53 (32–72)

0.565

Gender, male

86 (78.2%)

20 (52.6%)

0.005

Blunt trauma

106 (96.4%)

36 (94.7%)

0.647

Mechanism of the injury

 Traffic accident (in the car)

29 (26.4%)

13 (4.2%)

0.313

 Traffic accident (pedestrian)

29 (26.4%)

13 (34.2%)

 Fall

39 (35.5%)

10 (26.3%)

 Invert

6 (5.5%)

0 (0.0%)

 Stab wound/cutting

3 (2.7%)

2 (5.3%)

 Others

4 (3.6%)

0 (0.0%)

Injury to the admission to ED

 0–30 (min)

12 (10.9%)

9 (23.7%)

0.138

 30–60 (min)

64 (58.2%)

21 (55.3%)

 60–90 (min)

21 (19.1%)

3 (7.9%)

 90– (min)

13 (11.8%)

5 (13.2%)

Revised trauma score

6.72 (5.03–7.84)

5.68 (4.09–6.08)

< 0.001

Probability of survival

0.842 (0.630–0.943)

0.567 (0.230–0.832)

< 0.001

Vital signs on the admission to ED

 Heart rate (per min)

86 (72–105)

110 (86–120)

0.010

 Glasgow Coma Scale

11 (6–14)

6 (3–13)

0.035

 Systolic Blood Pressure (mmHg)

120 (99–151)

93 (68–137)

0.014

 Respiratory rate (per min)

22 (16–25)

21 (17–30)

0.489

Injury severity score

25 (20–32)

34 (25–41)

< 0.001

Abbreviated injury scale

 Head/neck

4 (1–5)

4 (0–5)

0.264

 AIS face

0 (0–0)

0 (0–1)

0.482

 AIS chest

3 (0–4)

3 (0–4)

0.104

 AIS abdomen

0 (0–2)

0 (0–3)

0.065

 AIS extremity

1 (0–3)

2 (0–3)

0.047

 AIS external

1 (0–1)

1 (0–1)

0.082

Blood gas analysis

 pH

7.35 (7.30–7.38)

7.24 (7.11–7.35)

< 0.001

 Base deficit (mmol/L)

2.5 (0.3–5.4)

6.95 (2.7–14.63)

< 0.001

 Lactate (mmol/L)

3.2 (2.3–4.7)

5.8 (3.6–10.0)

< 0.001

Laboratory tests

 Platelet (× 103/μL)

200 (147–235)

193 (146–234)

0.632

 PT-INR

1.06 (0.98–1.158)

1.22 (1.12–1.40)

< 0.001

 Fibrinogen (mg/dL)

193 (159–235)

156 (137–219)

0.034

 FDP (μg/mL)

76.4 (30.0–165.0)

99.5 (45.0–188.0)

0.349

 D-dimer (μg/mL)

47.8 (19.5–104.2)

58.3 (28.3–104.9)

0.633

  1. FC fibrinogen concentrate, ED emergency department, AIS abbreviated injury scale, PT-INR prothrombin time-international normalised ratio, FDP fibrin/fibrinogen degradation products